Whatfix can work on any web application. If you use a web browser to access your application, Whatfix content can be deployed on your application.
Here are a few video demos on how Whatfix content works in different applications.
Whatfix Demo on Salesforce
Whatfix Demo on Bullhorn
Whatfix Demo on Workday
Other Web applications that you can use Whatfix on include Successfactor, ServiceNow, SharePoint, Oracle, and more.